Background: To study different value of estimated glomerular filtration rate with normal serum creatinine whether\nis a risk factor for hidden renal function of cardiac surgery outcomes.\nMethods: A total of 1744 cardiac surgery patients with serum creatinine less than equal to1.2 mg/dL (female)/1.5 mg/dL (male)\nwere divided into 3 groups: estimated glomerular filtration rate Greater than equal to 90 mL/min/1.73 m2 (no renal dysfunction,\nn = 829), 60 less than equal to estimated glomerular filtration rate < 90 mL/min/1.73 m2 (hidden renal dysfunction, n = 857),\nestimated glomerular filtration rate < 60 mL/min/1.73 m2 (known renal dysfunction, n = 58) and followed up for\n3 years. Multivariate regression analyses for risk factors of postoperative acute kidney injury.\nResults: The proportion of preoperative hidden renal dysfunction was 67.1% among patients Greater than equal to 65 years old\nand 44.1% among patients < 65 years old. Multivariate Cox regression analyses showed that for patients < 65 years,\nknown renal dysfunction was a risk factor for postoperative acute kidney injury (P < 0.01) and progressive chronic\nkidney disease (P = 0.018), while hidden renal dysfunction was a risk factor for progressive chronic kidney\ndisease (P = 0.024). For patients Greater than equal to 65 years, only known renal dysfunction was a risk factors for 3-year\nmortality (P = 0.022) and progressive chronic kidney disease (P< 0.01).\nConclusion: Hidden renal dysfunction was common in patients with normal serum creatinine for cardiac\nsurgery, with a prevalence of 49.1%. For patients < 65 years old, hidden renal dysfunction was an independent\nrisk factor for progressive chronic kidney disease.
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